Harnessing the potential of the skin to heal the body
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To induce sebum secretion from the skin, both upstream and downstream pathways can be targeted.
The stimulation of skin keratinocytes by drugs such as Vitamin D3 can induce skin-derived factors (TSLP and others), which stimulate sebum secretion. Alternatively, the downstream pathways (TSLP and other skin-derived factors) can be directly administered to induce sebum secretion.
Meibum, a substance produced by inner eyelids, is also induced a similar manner. Some of these skin-derived factors can also enhance the expansion of an immunosuppressive subset of T cells known as regulatory T cells.
Together, these effects can translate into novel therapeutic strategies to treat inflammatory diseases, skin-related disorders, dry eye, and lipid metabolic disorders.